Is PML a Tumor Suppressor?
نویسندگان
چکیده
منابع مشابه
Is PML a Tumor Suppressor?
The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then syst...
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Growth arrest, inhibition of cell proliferation, apoptosis, senescence, and differentiation are the most characterized effects of a given tumor suppressor response. It is becoming increasingly clear that tumor suppression results from the integrated and synergistic activities of different pathways. This implies that tumor suppression includes linear, as well as lateral, crosstalk signaling. The...
متن کاملThe SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad spectrum of cancers, the tumor suppressor PML undergoes ubiquitin-mediated degradation primed by CK2 phosphorylation. Here, we report that the SUMO E3-ligase inhibitor PIAS1 regulates oncogenic signaling through its ability to sumoylate PML and the PML-RARA oncoprotein of a...
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our previous studies showed that the promyelocytic leukemia protein, pml, functions as acellular and growth suppressor. transient expression of pml was also found to repress the activity of theepidermal growth factor receptor (egfr) gene promoter. in this study, we have examined the effects ofpml on a431 cells, which express a high level of egfr protein. the pml gene was introduced into thecell...
متن کاملUbiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely understood. Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its role in tumor microenvironment regulation is poorly characterized. PML is frequently downregulated ...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2013
ISSN: 2234-943X
DOI: 10.3389/fonc.2013.00174